Podcast Episode: PCI-Wrap

Redefining the Outcome Equation for
Percutaneous Coronary Intervention

The REPLACE-2 Trial and Implications for and Integrated
Approach to Antithrombotic Therapy

• Introduction to PCI Wrap
• Overview and History of Antithrombotic Therapy
• The Challenge of Balancing Ischemic versus Hemorrhagic Endpoints
• Direct Thrombin Inhibitors
• Philosophy and Conceptual Approach to REPLACE-2 Trial
• REPLACE-2: Details, Structure, and Design of a Landmark Trial
• Risk Stratification Issues and Patient Profiles in REPLACE-2
• Summary of REPLACE-2 Results—30 Day Results
• REPLACE-2: The Mortality Question—One Year Outcomes
• Clinical Implications of REPLACE-2 Trial
• Beyond REPLACE-2: The ACUITY Trial and Antithrombotic Therapy
• Conclusions
   

Presented by: A. Michael Lincoff, M.D.